Anuradha Sriram first entered the Tamil Cinema Industry as a child artist in the 1980 Tamil movie Kaali. In 1995, she was introduced as a singer by A R Rahman for the song "Malarodu Malaringu" in the movie Bombay. Her first solo was for A R Rahman in Indira.

She specialises in Carnatic music and has sung in over 1000 concerts worldwide. She is keenly interested in folk music. She has featured in a number of jugalbandhi or fusion concerts along with her husband, Sriram Parasuram, a Hindustani maestro. She has sung more than 3000 songs in various languages.